in Autism Spectrum Disorders (ASDs)
researchers have studied the hearing status and auditory features of children
with autism or autism spectrum disorders (ASDs). Ali A. Danesh (Florida
Atlantic University, United States) described how abnormalities of the auditory
system can result in hearing loss, tinnitus, and hyperacusis (Danesh &
Kaf 2015). Additional auditory abnormalities
may include inability to localize the source of a sound and difficulty
understanding speech, particularly in noisy environments (Giraud et al.
1995; Danesh & Kaf 2015). Of these problems, hyperacusis is
probably the most common. Unusual behaviors such as social avoidance and
exaggerated covering of the ears are two common traits in the ASD population
and these are a result of an emotional response to sounds via stimulation of
the limbic system and the autonomic nervous system (Ecker et al.
2012; Abrams et al. 2013; Moller et al. 2005). This behavior suggests a defensive
response to an obnoxious stimulus. When this behavior is exaggerated it
manifests itself as hyperacusis. Previous studies have shown that hyperacusis
occurs in 18% of individuals with autism (Rosenhall et
al. 1999). Danesh et al.
(2015) reported that 38 out of 55 patients
(69%) with Asperger’s syndrome had hyperacusis and 19 (35%) had tinnitus.
could be a sign of auditory pathway problems or a sign of abnormalities in the
limbic system (Gomes et al. 2004; Stiegler & Davis 2010).
It has been suggested that the limbic system generates a negative emotional
reaction to sounds and relays it to the auditory cortex. The auditory cortex in
turn triggers the perception of the negative reaction, causing hyperacusis (Katzenell & Segal 2001; Nigam & Samuel 1994).
However, clinicians should be aware that hyperacusis in the ASD population may
originate from other and less expected factors. An imaging study on 14 subjects
with ASD investigated the relationship between hypersensitivity to sound and
superior semicircular canal dehiscence disorder (Thabet & Zaghloul 2013).
This is a disorder where the bone between the superior semicircular canal and
the cranial vault is very thin or absent and its incidence in the general
population is about 2% (Carey et al. 2000). Remarkably, Thabet and Zaghloul
(2013)reported that 29% of individuals with ASD combined with hypersensitivity to
sound had superior semicircular canal dehiscence as revealed by CT imaging.
cases of hyperacusis may be linked to reduced effectiveness of the efferent
pathways in the auditory system (Tyler et al.
2014). One aspect of the operation of the
efferent system can be assessed by recording otoacoustic emissions (OAEs) with
and without contralateral noise stimulation; this assesses the integrity of the
medial olivo-cochlear bundle (MOCB) pathway (Giraud et al.
1995). It is well known that reduction of
OAE responses by contralateral stimulation reflects the normal inhibitory
function of the MOCB on the outer hair cells (Collet et al.
1992).Danesh and Kaf
(2012) measured distortion-product OAE
(DPOAE) amplitudes for children with autism and compared them with those for an
age-matched control group. In the absence of noise, the DPOAEs amplitudes were
reduced for the children with autism, suggesting cochlear dysfunction. When
DPOAEs were recorded in the presence of contralateral noise, the suppression
effect was weaker for the children with autism than for the control group,
suggesting dysfunction of the MOCB. The findings of Danesh and Kaf
(2012) may explain why many children with
autism suffer from hypersensitivity to sounds and difficulty hearing in
background noise, since the efferent system appears to play a role in the
latter effect (Giraud et al.
similar study Kaf and Danesh (2013)measured DPOAEs and contralateral suppression in children with Asperger’s
Syndrome (N=18 males) and an age-matched control group. Interestingly, there
was no significant difference in DPOAE amplitudes and contralateral suppression
between the two groups. Comparison of the studies of Danesh and Kaf (2012)and Kaf and Danesh (2013)suggests that the diminished OAE suppression effect may provide
neurophysiological evidence for reduced MOCB function mainly in children with
low-functioning autism, but not in children with high-functioning autism.
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